Let's face it, epic is all about exploiting the weak AI of the game and high hit point damage per second. Sure, there are some minute tactical choices that don't involve exploiting the AI, but they are more "choose this spell, let melees beat on things" than actual tactics.
Then, there's being a melee. As everybody knows, all you shoot for is hit points and saves. Armor class is useless unless you can obtain one that's absurdly high. In order to do so, you pretty much must sacrifice so much damage output that you might as well be tickling the enemy with a feather duster. I will grant that this mirrors PnP, where at high level every melee (including the enemy) states the same thing every round: "I full found attack with full power attack." Just because this is true does not mean that DDO should follow suit.
What would I like to see? Adjustments to enemy attack bonuses and attack rates (lower attack bonuses, increase attack rate) to make armor class worthwhile. Remove blanket immunities (with the sole exception to Vorpal, which should not be an ideal choice of weapon). Allow stat damage to be a good way to deal with the enemy (in PnP at this level you're a moron if you're trying to use hit point damage anyway, but I wouldn't go that far either). Really, the focus should be on making characters that aren't high DPS meatsacks more useful.
As far as spell usage goes, we need more options. Force Cage, Imprisonment, Prismatic Sphere, Maze (heck, we already have the graphic from the banishment effect of prismatic spray/ray), etc. I will grant that some of these are similar to Otto's Irresistable Dance (but worse, in a way, since often the subject cannot be attacked), but at least some are of a different level. Imprisonment is the grand-daddy of Trap the Soul, but at least it is a touch spell. Making debuffing useful would also be nice.
I, mostly, would like to see Epic be more than just a war of attrition between PC DPS, PC healing, and monster DPS (with the deciding factor being that monsters are incredibly stupid). I'd also like to see spell casters have more options than just Wall of Fire, Mass Hold Monster and Otto's Irresistable Dance.
I'm sure I'll catch some flak for this, oh well. It's just my 2 cp.