I am farming for an Isle of Dread end game set with 2 attuned weapons, 1 cloak, 1 minor artifact and 1 named item.
Getting the two attuned weapons and the cloak means running the raid many items. As the raid has so very many items getting the ones you want as drops doesnt happen that often so its mostly farming the runes.
Earlier I farmed the T-rex while is was easy and the 2 crest named. I was 2-3 boxing ransacking both for several weeks so I now have 1100ish black pearls which is more than enough. I wonder though how much time that would take for someone that cant solo these spawns (and the T-rex is much harder now) with just 1 character.
I am also farming fossiled ings. I am 4 boxing a couple of rares near the Up River port in spot. I figure I can loot 50 chests in an hour - but it is still pretty slow going.
Overall, I consider the farming a bit excessive. I am going to do once maybe twice but after that I doubt I will farm for a 3rd build - and thats with a raid guild and the ability to multi-box while the raid is new. Late comers and those that use PUGs for raids will have a really hard time I expect.
Maybe I am just blowing smoke, too lazy or something even less flattering but I find the Isle of Dread gear system excessively heavy on farming in a boring way. Maybe even more so than old slavers!