Generally speaking, in regular quests that I have run (at least on LE), things seem pretty much the same. I went into quests ignoring my new stats and just tried to see how it "felt". I seemed okay.
However, in Dryad and the Demigod, this really felt much different and I was quite saddened as it was a fun raid that a casual person could join in on. Very approachable, even on Hard. My initial try at Hard post U50 and monsters seemed to be hitting much harder than before. I was even killed by a beetle for >1000 damage (on Hard mind you). I'm a SB and was still able to Coup de Grace the beetles at least. I was also able to still Bluff the giants (rolled a 1 on a 79 now - but don't know what is needed minimally yet).
We failed at the raid - twice. I okay dying in there (and probably do due to some mistake I make every third run or so), but this was just a whole group - wiping twice. I'm hoping the devs take a look at the damage and adjust as needed. I would love to continue to run this raid - as it felt before. It was just fun. Now it has more of a feel bad adjustment.
Admittedly, it was only a single night, but it was 1 of my top 3 characters who always contributes. I just died to easily and quickly.
Thanks for reading!
Taleisin