With U45's focus on realigning ranged damage so it no longer overshadows melee dmg, there's something that hasn't been mentioned: Making Project Nemesis more accessible to melee.
Melee are currently redheaded stepchildren in Project Nemesis:
1. Cannot effectively DPS Irk or Zulkis.
2. Increased chance of dying from Rudus' superman jump due to the ever present lag in the raid.
I would have added a third about the DPS loss of running in and out of battery room circles that are cast every 3 seconds, but I think that's been largely addressed by the welcomed "Charge" changes.
Because of these two issues, ranged are currently preferred over melee in Project Nemesis. With the U45 range damage adjustments, ranged is much less desired than pre-U45. However, there's still a disincentive to bring melee because of #1 and #2. Instead the post-U45 meta will shift to bring more nukers to replace the inferior ranged toons.