Been having this issue for about a month or so. Randomly in game, my screen would lock up, keyboard and mouse becomes unresponsive causing me to do a hard reset on my computer in order to log back in.
System:
Windows 10 Home 64-Bit Operating System, x64-based processor
CPU: Intel(R) Core(TM) i7-6700HQ CPU @ 2.60GHz
GPU: NVIDIA GeForce GTX 960M 4GB
Memory: SK Hynix 16.0 GB
Last night, thinking it maybe a corrupted windows installation I contacted microsoft and spent 3 hours or so updated the drivers, did a in-place installation of Windows 10 Home and clean boot, memory diagnostic test which no errors of any kind came up. Everything on my laptop is up to date. I also uninstalled the game twice and reinstalled the game in two separate folders and still getting the issue. I tried running it as administrator and still same problem. I can run my other games just fine as far as I can tell but I seem to have an issue with a 14 year game.