FIXED!
I just ran into this issue on a brand new build. I upgraded my system and installed windows 10 pro fresh. Did all the updates then installed DDO. It wouldn't let me make any changes to the graphics without the error message shutting down DDO. DDO would run fine if I didn't make changes to the graphics.
Also the direct X 9 was grayed out and wouldn't let me change it.
After much research and banging of my head against the desk, I found this:
https://www.microsoft.com/en-gb/down...ion.aspx?id=35
Once installed, all issues were resolved.