When I run DDO, the game looks fine, but everything else on my computer suddenly looks faded and washed out. This persists until I close DDO.

I've had this problem in the past (probably back on Windows 7; now using Windows 10). I don't know what fixed it, but I this time I have recently reinstalled the game, so I suspect there's some graphics setting that I "fixed" before and need to do again.

Any ideas?