This happened earlier. Fortunately, I was at the end fight and killed the boss. This was a quest where you had to do a lot of targeting with the T key - and I don't like doing that - but anyhow at the end of the quest I may have done something with my clumsy fingers and ALL of my shortcuts - all like where my gear is stored, character information, chat box etc. It all went bye bye. I was able to know I had finished the quest by typing X and the experience log came up.
I "quit the program" from the ESC key and when I logged back on I did get credit for the quest and my bars/shortcuts etc. were all restored.
So the question is did I hit something accidentally
And how do I restore if my clutz fingers do it again.