A case could be made for Thematic dexterity based assassination. One of the most impossible things about assassinate is not its ability to kill with one well placed blow or cut. It is the ability to do so while remaining unseen and not breaking stealth. That is all superhuman agility and speed.
Thematically a character would need a certain base line amount of dexterity intelligence and strength to pull this off. Dr. Stephen Hawking with dump stats in dex and strength wouldn't be able to do this. A top athlete like a Olympic gymnast or a nfl corner back however would not need a great deal of anatomy training to make this a plausible scenario though.