Originally Posted by
Tilomere
Both splash and main rogue work.
The only consistent way to land sneak damage against everything in the game is Tier 6 shadowdancer, which requires attacking with a weapon, and not unarmed as a monk or druid. A 3 Druid 4Fighter 13 Rogue would generally tear everything up that is not immune to sneak damage, but only be good against sneak immune mobs with a MF weapon. This also requires enough twists for self healing (consecrate/sacred ground) and Balanced Attacks helpless effects (3-3-2 twists). Probably also want to be an elf with extend feat and displacement dragon mark enhancement.
With lower twists, you need to rely on Druid healing or divine crusader, which means less rogue levels or melee power sneak dies.