I've been thinking about it and one of the things I remember from the lil bit of P&P i played over the years was DM i had at one time came up with a great idea for a campaign were you got to the end, and all of a sudden 1 or 2 of the party members came under control of what he called "That Charming Fellow That Everyone Hates".
Basically the last fight in the campaign was against the charming fellow and 2 of the party members who came under his control. The party members recieved buffs and were forced to fight the rest of the party, if they won, he gave them pretty unique items, if they lost the rest of the party recieved loot from the normal table.
So my idea would be to make a quest like this where one or two of the party members are selected at random before the end fight and are given buffs (say 25% to ability scores/dcs/saves/etc on casual, 50% on norm, 75 on hard and 100% on Elite) and if they can destroy the party they get a special chest to loot, and the party maybe gets a regular chest with some not so great stuff. IF the party wins, they get their own special chest with different loot. TO combat the whole (groups will exploit and have to two evil ones pike and do nothing or vice versa) make it akin to the spectral dragon fight from mabar where the group is select at random from a group of qued players only no one can enter the que if they are in a group. That way you will get an entire group of random players with hopefully lil ties or loyalty to one another making it a fair quest free from exploiting.
Also the winning team gets a completion and are put on a 7 day timer (yes 7 days). The losers are free to retry the quest as much as they can stomach.
I think this would make a very interesting addition to DDO in that it will be one quest that is literally never the same each time you run it.
I don't know how feasible this would be with DDO's current engine but it does not seem an impossible task to pull off.