Am not at the right PC at the moment to test, but I remember last year installing a recent version of OpenOffice and after doing so, DDO wouldn't run. I can't recall what the problem was, but I -think- the launcher got stuck.

Of course I will test this completely when I get to the right PC and have some time, but I thought I'd ask in here in case anyone else came across this and could save me a bunch of time by telling me what they did.