Well there has been a lot of people reporting long loading, dc upon loading and freezes.
In my case i had all three, long loading screen, red link during or after loading screen and small freezes all around.
Tried a bunch of things so the solution may vary for each computer.
So far what has seemed to work best was to bump up textures cache all the way to max.
This seemed counterintuitive at first. I have previously kept it at default because i have limited ram.
However, it seems that after each loading screen it all goes to pagefile and do not bother you at all while in quest.
(ddoclient is still limited to 2G in the pagefile, or the taskmanager shows it that way)
This miraculously got rid of the long loading screens both initial and in quests/areas.
Since the loading is no longer delayed or stuck the "false starts" with redlink or timeouts are not happening anymore.
The small freezes still happen but much less often, mostly mere drops in fps and go away faster.
This was on a system that is decidely low on resources but could run on minimal graphics.
It already ran on high priority, had a readyboost stick, and set pagefile over 9000
The texture cache hints that there's a larger size in the loading, while the data frag leak was vanquished recently
there might still be that the game files have grown with the expansion.
The other thing that changed was updating realtek drivers from 2007 to 2012.
Sound was a suspect because every time the music changed there was a small freeze.
But that alone didn't prevent the long loads, only the textures cache helped with that.