Trying to analyze what type of characters are builds are winners and losers. I have had the following thoughts:
Most the changes happen in the epic levels, except the AC and related effects happen also in heroic.
List of probable losers:
Anyone in pyjamas who is not a pure/near pure monk-As other armor types get a buff, the unarmored category gets much harder to get a relevant AC unless you are mostly a monk that thus gets the extra increases for monks.
AC tanks: you cannot get the near invincibility you had before.
Palemasters/necro archmages. The new epic ward makes the bad old days be back where wizards are there for holds only.
Bards: They will fall further and further into a role of buffbot, with the difficulty of getting things like the heal spec epic destiny.
Healers: as the tanks will likely take more damage.
Clonks and other melee divines: The stance changes, AC changes and such makes it much harder to melee at same time as you cast.
Caster divines: will get also hurt by the epic ward and with the healing difficulty..
Probable neutrals with changes:
Barbarians: They can again get damage migation level armor class, but the cleave nerf and not hiotting always on 2 hurts.
Rangers: The AC changes likely hurt as in getting hit more, but likely benefit from the hit probability as many such had hard time hitting the tougher enemies and if range specked from the ranged epic destiny.
Rogues: the AC changes should benefit them as most rogues should reach reasonable AC and good dodge. But the epic ward will make assainate useless.
Probable winners:
Sorcerors: the epic destinies give them more nuking than ever, along with the lower enemy HP on epic quests.
Any melee that did not have top to hit probablity as they will hit a lot more often and can also often get reasonable damage migation with armor.
(More thoughs and changed ideas likely after actual testing, above is based on earlier beta versions, release notes and other reading)