It also depends on your build and how complex you want to make the game.
I will say, I use a PS3 controller & Pinnacle Software (Started with a Logitech, before they started to suck), because I have issues with my hands as well. Not really sure what kind of set up to provide you, but perhaps even something like a Wii Nunchuck Controller or Milti-button mouse might help you with limited hand movement ability. Can any hard core computer gamer validate if this can be done?
(added: It seems that Wii can use Bluetooth. so if the computer has Blue Tooth, so maybe you can use something like this
http://www.amazon.com/Wii-Nunchuk-Co.../dp/B000IMYKQ0 to make moving in the game a little easier, something to consider)