I'll recommend my guild, the Knights of the Silver Dragon.
You can find their recruitment post here:
http://forums.ddo.com/showthread.php?t=321744
My husband and I both joined late last year, and we've come to really enjoy playing DDO since doing so! They're a very structured, but casual oriented, guild of competent and friendly players. I can vouch for them being both patient and thorough about explaining what's going on to new players, because they've been fantastic about teaching us the ropes.
Good luck to you wherever you choose to join!