Hmm - this is an issue - it seems that if you die in the Nurse Ratchet fight, neither you nor your soulstone will be teleported out of the room. As the room is then locked, your companions cannot reach you. There is obviously no shrine in reach.
This basically means that if you die in the Nurse Ratchet fight, you win the quest but cannot loot the chest (can't exit and re-enter as the quest is finished at that point unless you held off speaking to Durk as a safety net).
This is based on hireling observations - haven't tried this in a group.