Try Alpha Protocol. It got somewhat panned by critics, but it was mostly for bugs which have since been fixed.
The gameplay is very similar to Mass Effect 2 (FPS/RPG with "powers"), although it's a bit more stealth-focused, like Deus Ex or Splinter Cell. It's made by Obsidian, and a lot of the guys that worked on it used to work at Troika, where they were involved in your favorite game, VTMB. (Which is also one of my favorite games.) The premise is a modern-day "spy thriller" like a James Bond movie or The Bourne Identity.
I liked it quite a bit. I liked Mass Effect 2 quite a bit more, but Mass Effect 2 is my favorite game to come out since VTMB.
If you've never played Deus Ex, though, and you don't mind a somewhat older game, play that instead. It sounds like you and I have pretty similar tastes, and I can tell you that Deus Ex is hands-down my favorite game. Not from nostalgia, either -- I first played it just a couple of years ago. The graphics aren't great anymore, but the gameplay and story are first rate.