Ghosts of Perdition is one of the hardest quest if you don't know what you got.
Until you reach the Doomsphere it is really simple, then things can get messy.
The Doomsphere is a lawful good ghostly beholder. It is immune to almost everything except physical, acid and force, undead bane and chaotic.
To kill the Doomsphere you need Ghosttouch (either weapon or on items like spectral gloves).
To survive the fight you need greater cold resistance item (lightning resi is also nice, since the skeleton mages do cast a few of them too), deathblock, either some way to get rid of Negative level (Greater Restoration, though it can fail) or better radiant servant burst or/and a way not to get negative level (beholder optic nerves, silver flame trinket (T2 or T3), Warforged, Pale Master (in form)).
With the above items just gang up on the Doomsphere and kill it as fast as possible, ignore the mobs.
Regards Tore