I've been having an issue where I'll crash at area transitions. This has happened going to Sands, Ataraxia, into Quests and various others. Others I've talked to are also having this issue. I've reinstalled the game and made sure my graphics drivers are completely up-to-date. I've also sent a ticket to Turbine as well. Here is my DXdiag listing if its at all relevant:

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System Information
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Time of this report: 6/21/2010, 20:20:49
Language: English (Regional Setting: English)
BIOS: BIOS Date: 03/07/06 21:56:46 Ver: 08.00.12
Processor: Dual Core AMD Opteron(tm) Processor 185 (2 CPUs), ~2.6GHz
Memory: 2048MB RAM
Available OS Memory: 2048MB RAM
Page File: 1097MB used, 2997MB available
Windows Dir: C:\Windows
DirectX Version: DirectX 11
DX Setup Parameters: Not found
User DPI Setting: Using System DPI
System DPI Setting: 96 DPI (100 percent)
DWM DPI Scaling: Disabled
DxDiag Version: 6.01.7600.16385 32bit Unicode

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DxDiag Notes
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Display Tab 1: No problems found.
Sound Tab 1: No problems found.
Sound Tab 2: No problems found.
Input Tab: No problems found.

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DirectX Debug Levels
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Direct3D: 0/4 (retail)
DirectDraw: 0/4 (retail)
DirectInput: 0/5 (retail)
DirectMusic: 0/5 (retail)
DirectPlay: 0/9 (retail)
DirectSound: 0/5 (retail)
DirectShow: 0/6 (retail)

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Display Devices
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Card name: NVIDIA GeForce 8800 GT
Manufacturer: NVIDIA
Chip type: GeForce 8800 GT
DAC type: Integrated RAMDAC
Device Key: Enum\PCI\VEN_10DE&DEV_0611&SUBSYS_06DC19F1&REV_A2
Display Memory: 1267 MB
Dedicated Memory: 499 MB
Shared Memory: 767 MB
Current Mode: 1680 x 1050 (32 bit) (60Hz)
Monitor Name: Generic PnP Monitor
Monitor Model: SyncMaster
Monitor Id: SAM027F
Native Mode: 1680 x 1050(p) (59.883Hz)
Output Type: DVI
Driver Name: nvd3dum.dll,nvwgf2um.dll,nvwgf2um.dll
Driver File Version: 8.17.0012.5721 (English)
Driver Version: 8.17.12.5721
DDI Version: 10
Driver Model: WDDM 1.1
Driver Attributes: Final Retail
Driver Date/Size: 6/7/2010 19:57:00, 9712744 bytes
WHQL Logo'd: n/a
WHQL Date Stamp: n/a
Device Identifier: {D7B71E3E-4551-11CF-186C-D0261CC2C535}
Vendor ID: 0x10DE
Device ID: 0x0611
SubSys ID: 0x06DC19F1
Revision ID: 0x00A2
Driver Strong Name: oem22.inf:NVIDIA_SetA_Devices.NTx86.6.1:Section003 :8.17.12.5721: pci\ven_10de&dev_0611
Rank Of Driver: 00E62001
etc...
D3D9 Overlay: Supported
DXVA-HD: Supported
DDraw Status: Enabled
D3D Status: Enabled
AGP Status: Enabled