Okies the most common problem i see with vista users is that the games icon shortcut is broken in the games folder and iv told many peaple how to fix it so here it goes....
games>dungeon and dragons icon>right click it.... go to customize>click add>browse>computer>local disk c(or what ever u got it installed 2>program files>turbine>ddo folder> and find the dnd launcher icon.... click it then, click ok
this seems to fix this little problem and u never have to deal with it again :P
hope this helps any one who encounters this problem
Have a good day