Many years ago, the practitioners of the Silver Flame purged the continent of Khorvaire of most, if not all, of the lycanthropic races. Werewolves, weretigers, wererats, were-anything were slaughtered by the score all across the continent by humans who simply didn't want to become lycan.
Is it possible that some of those lycans managed to escape to Xen'drik?
I'd like to propose a new quest chain, where followers of the Silver Flame ask adventurers to clear out a group of lycans living in the jungles of Xen'drik.
Similar to the Shan-To-Kor missions, the party will enter a village of a monster race, but the mission given by the Silver Flame will include a bonus for killing a certain number of the hated creatures.
One of the many fun side-effects of fighting lycans in pen and paper is the chance of a party member being infected with lycanthropy during the battle, or unexpectedly during a conversation, a dinner party or a vigorously pleasant evening. We can simulate this by having the party contract lycanthropy as a hidden condition during an early mission, only to first show the symptoms during a later mission, and that entire mission can be skipped or altered if the entire party was afflicted, since newly afflicted lycans don't typically remember their first transformation in 3.5 rules.
Party members who continue to be afflicted could have the chance of transformation during battle, although I think that would break the art budget, so perhaps party members would just benefit from the dr/silver and the bonus to wisdom while fighting the very members of the Silver Flame who sent them to fight the lycans in the first place.
At any rate, I think the lycans could have 'kidnapped' or turned a loyal follower of the Flame, or a child of such a person, and the main story line could revolve around rescuing said person from them, hopefully reversing the curse in the process, if the person has been afflicted.
During the process of pursuing the rescue, the chance of being turned by the lycans can occur when bitten by wolves or rats during a mission, or it can happen in a non-combat situation scripted any way the Turbine team chooses to do so.
After the party has been afflicted, they should be given the choice of joining the lycans' side against the Silver Flame.
Regardless of the decision the party makes, there should definitely be a showdown with the priests of the Flame at the end of the series as they attempt to purge the world of every last bit of lycanthropy.
Thank you for your time. You may now resume your regularly scheduled whinefest about 32-point builds not being in the store, and the lack of druids.