I'm not sure how you guys managed to get the game running in Vista, but I had to go through pains to get it running on a friend's Vista computer, being that the .NET Framework used is version 1.0, and using the default Microsoft .NET Framework 1.0 redistributable from the Microsoft website won't install nicely with Vista. Retargetting the launcher to use .NET Framework 3.0 should solve the problem, as Vista (and Windows 7) comes with the framework integrated, and hopefully it should bring in more users to DDO.