I have read all of the replies to your questions ALAVATAR. I have been playing for 2 years with this set up with superb performance and none of the troubles mentionned here.
First, know that the max resolution supported by DDO online is 3840x1024. This resolution is available with many games now.
Second, know that your 3 monitors have to be IDENTICAL. Otherwise you will face the problems here mentionned. That means you should be using monitors of (3840 divided by 3) 1280x1024. This way you get no distorsion of image from one screen to the other and it wont reset to the main screen all the time. I have tried to put 1900x1200, with 2 1280x1024 on each side and it looks terrible. Dont do that.
It does not matter the number of graphic cards you have (quality and performance matters though big time).
Use MATROX TRIPLEHEAD-TO-GO.(check the website). Super easy! It is an external graphic expansion module. PLug it in your graphic card. Plug the monitors into the module. Install software and you are ready!! The image automatically resize across the 3 screens, according to the resolution you set it at.
If you want max graphic settings (ultra-high) 3840x1024, will need a heavy duty gaming rig. I used nvidia 7900 oc BFG on medium setting for optimal peformance. Now I have nvidia GTX 260 SLI on ultra high
Now with that kind of resolution, put your hot bars or what no where ever you want it: Left screen has full map, all chat windows opened, center only has life bars and orb, right screen has all 20 hotbars stacked, inventory opened and dungeons goals.
Matrox has now a digital version of their first analog 3-head-to-go.
Really worth it!