I'm not yet to the point of yelling, but the perpetual gloom is getting old. The weather needs to vary. Does it ever snow in Stormreach?
I've heard mention that we'll be getting more shortcut bars. We need a UI overhaul in general.
Managing my inventory would be faster and easier if it had a sort feature. Sort by type; useful when I want to pick which weapons to keep or get rid of. Sort by time acquired; useful when I want to look over the loot I just gathered. Or, since the game presumably doesn't timestamp items, allow items to be flagged, with an option to auto-flag an item when it's looted from a chest or given as a reward, and then let me autosort my inventory by flag.
I do want more shortcut bars, but not all on the screen at once. What I really want is to be able to toggle between entire sets of shortcut bars. Set 1 is fairly small and includes my "in-town" and traveling stuff-- haggle ring, expeditious retreat, greater heroism, healing spells, "Quenched" item, etc. Set 2 includes my buff spells and a list of all the gear I wear into combat. Set 3 occupies the most screen space; it has all my offensive spells, healing spells, buffs I cast in combat, wands, scrolls, my cartouche, all my combat weapons, and my activated combat feats. Set 4 would be my rogue items and skills, except that I don't play a rogue. And so on.