Here is my hotkey setup for those interested. Took me years to perfect it. My setup keeps all my important functions near the WASD keys for optimal speed. WASD/Mouselook mode is by far the most efficient mode for melee in DDO.
Most important keys:
F - Rage
C - clear fatigue (lesser restore potions x100)
X - Rage potion
Z - Haste potion (this defauls to examine i think, but personally I find examine to be too useful so i put it on a side mouse key)
G - Cure Serious potion
Ctrl + Z - Dismiss rage (nessary when you need a full rage bar for a boss and you dont wanna hold up your party)
Q/E - Not much use when in mouselook mode, but sidestep left/right when in chestloot mode.
R - defaults to auto run so i dont mess with it.. just be careful not to hit it at the wrong time
V - show names/off on, that works
Madstone rage throws a wrench into this tho.. So the the lesser restore becomes impossible due to the lame bug.. In general i ignore it try to get hurt so the cleric heals me to clear the fatigue lol (this is a big deal i dont like clerics who try to heal me with cure serious/crit) .. But sometimes ill ask for the lesser restore if im in a chatty mode.
So a normal routine goes - watch the timer carefully.. When it runs out (or when you dismiss it ), hit C, X, F.. Clear fatigue, drink rage potions for additon rage length, then rage. Takes several secconds and has to be done mid combat at times, but its worth it even if your under heavy attack.
Other good hotkeys I like:
B - for boots, madstone boots clicky
5/6 - DR boost/Sprint boost, i think the 5/6 keys the easiest to press and one of the most often i thit so it works nicely.
4 - power attack, you need that on a quick toggle too encase your to-hit suddely drops due to debuffs/loss of rage, whatever. Generally its left on tho 90%.
3 - trip, important ability must be used as soon as cooldown drops
2 - improved uncanny dodge, this has no cooldown and its a nice buff so i burn thru all my uses quickly, why not.
1 - ehh dont use this much find it ackward to press
7+ rarely used also due to being far away from WASD
Mouse buttons/New one i got for mod6:
Big Side mouse button - stunning blow.. Great ability and important ot have quick access to it. Before this was sunder.. Might have to find a new key for sunder..
Small side mouse button is examine - for quickly checking myself for buffs missing or checking boss stats or debuffs.
Middle mouse button defaults to look mode, so you can get an idea of what you party members are at behind you while you face foward to swing, important to keep track of all side of the battle.
Note you can put most of theese hotkeys in underneath bars where they dont even need to be seen. Tho some like potions must be on top to be seen and quickly replaced if they run out.