Since Mod 8 came out I had experienced crashes with the game at random times.
In short, the sound would stutter and the whole system would lock up and sometimes give a BSOD. It always seemed to happen when the character would spin around to the right.
I have a possible solution:
I have a SoundBlaster X-Fi XtremeGamer card running under Vista 64-bit SP1. In the Audio Control pannel disable X-Fi CMSS-3D and EAX Effects.
What I assume is happening is that the sound card is getting confused creating 3D Surround sound from the stereo.
Something must have been changed for Mod 8 because prior to this there was never a problem.
P.S. I am currently running Windows 7 64-bit and the game would still crash with CMSS-3D enabled.