If you have Seeker +6 on Marilith Chain or a pirate hat, freeing up the trinket slot for the Epic Gem of Many Facets can give you some choices.
If you have heavy fort on a MinII, DT armor or Epic Infested Armor, you could wear something else in the bracer slot.
You would probably have to give up 10% healing amp or +2 exceptional CON but it might be viable for some builds.
Edit: Epic Mask of Comedy is an excellent clicky and one which I constantly use on my Fighter. I'm amazed at how few melee even carry the base item. 5-15 minutes of +2 to damage when no Bard is in the group is a great buff.