it depends on the class some melee focused classes will have to hit problems later on in epics like bards (bab 15) or paladins ( to much stat spread to spike strenght through the roof) and no to hit enh either like for example rogues or fighters so having destruction on yoru armor basicly gives you +4 to hit. the +6 seeker or +10 seeker from marilith chain isnt gonna do a lot when you cant hit your oponents

for barbarians the to hit isnt that much of a problem tho so i would suggest going all out damage wich would be epic marilith chain